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4 For transdermal drug delivery, the rate-limiting barrier for a compound to be absorbed into the systemic circulation is the stratum corneum, which is the keratinized layer of the skin. 1999). It was argued in [27] that, due to the above-mentioned finiteness of the set of allowed discrete values of the central charge deficit δc, the Universe could reach flat four-dimensional Minkowski space-time, and thus exit from the expanding phase, after a finite number of phase transitions.

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